INDOCYANINE GREEN

Synonyms. Indocyanine green; Cardio Green; 2-(7-(1,1-Dimethyl-3-(4-sulfobutyl)benz(e) indolin-2-ylidene)-1,3,5-heptatrienyl)-1,1- dimethyl-3-(4-sulfobutyl)-1H-benz(e)indolium hydroxide sodium salt; Anhydro-3,3,3',3'-tetramethyl-1,1'-bis(4-sulfobutyl)-4,5,4',5'- dibenzoindotricarbocyanine hydroxide sodium salt; Cardio-Green;

INDOCYANINE GREEN 

Click for original image

 

PRODUCT IDENTIFICATION

CAS RN

3599-32-4

EINECS RN

222-751-5

FORMULA

C43H47N2NaO6S2

MOLE WEIGHT

774.96

H.S CODE

 3204.90.0000

SMILES

 c12c(N(CCCCS([O-])(=O)=O)C(\C2(C)C)=C/C=C/C=C/C=C/C2=[N+] (c3 ccc4c(c3C2 (C)C)cccc4)CCCCS (=O)(=O)[O-])ccc2c1cccc2.[Na+]

CLASSIFICATION

Coloring agent, Cyanine dye

EXTRA NOTES

A tricarbocyanine dye that is used diagnostically in liver function tests and to determine blood volume and cardiac output.
Other RN: 58984-23-9

 

PHYSICAL AND CHEMICAL PROPERTIES

PHYSICAL STATE.

dark green to black crystalline powder

MELTING POINT

 

BOILING POINT

 

DENSITY

 

SOLUBILITY IN WATER

 

SOLVENT SOLUBILITY

 

VAPOR DENSITY

 

log P(octanol-water)

  

VAPOR PRESSURE

  

AUTOIGNITION TEMP

  
pK

 

REFRACTIVE INDEX

 

FLASH POINT

 

 

STABILITY AND REACTIVITY
STABILITY Stable under normal conditions.

INCOMPATIBLE MATERIALS

Strong oxidizing agents

POLYMERIZATION

Has not been reported

NFPA RATINGS

Health: 1, Flammability: 0, Reactivity: 0

 

EXTERNAL LINKS & GENERAL DESCRIPTION

USA.gov - Indocyanine green

Wikipedia Linking - Indocyanine green

Google Scholar Search - Indocyanine green

Drug Information Portal (U.S. National Library of Medicine) - Indocyanine green

PubChem Compound Summary - Indocyanine green

KEGG (Kyoto Encyclopedia of Genes and Genomes) -  Indocyanine green

http://www.ncbi.nlm.nih.gov/ -  Indocyanine green

Material Safety Data Sheet - Indocyanine green

Hazardous Substances Data Bank - Indocyanine green

EPA - Substance Registry Services - Indocyanine green

http://www.sigmaaldrich.com/
Cardiogreen is a negatively charged polymethine dye that forms noncovalent fluorescent complexes with proteins. This "pseudofluorogenic" property has been utilized for protein determination by capillary electrophoresis with diode laser-induced fluorescence detection.1 Cardiogreen has been used to resolve several labeled proteins including: human serum albumin, ribonuclease A, transferrin, and cytochrome c.

http://omlc.ogi.edu/ - Optical Absorption of Indocyanine Green (ICG)

 

SALES SPECIFICATION

APPEARANCE

dark green to black crystalline powder

ASSAY

95% min

LOSS ON DRYING

6% max

 

TRANSPORT & REGULATORY INFORMATION

UN NO.

 

HAZARD CLASS

 

PACKING GROUP  

 

SAFETY INFORMATION

HAZARD OVERVIEW

OSHA Hazards: Irritant. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

SIGNAL WORD Warning

PICTOGRAMS

HAZARD STATEMENTS

H315-H319-H335

P STATEMENTS

P261-P305 + P351 + P338

EC DIRECTIVES

 

HAZARD CODES

RISK PHRASES

36/37/38

SAFETY PHRASES

26-36

 

PACKING

Preserve in light-resistant and well-closed containers